Fuzzy zeros in percentile normalization method to correct for batch effects

We recently published a method to normalize data that corrects for batch effects and allows for pooling of raw data across studies. In this post, I want to discuss more about the important (but potentially confusing) aspect of our method, where we add noise to the zeros before performing the normalization. I’ve gotten a few …

Microbiome Bioinformatics Postdoctoral Scientist, Colorado State University

The Metcalf lab at Colorado State University is seeking a microbiome bioinformatics postdoctoral scientist. The scientist will analyze multi-omics data sets, including but not limited to: amplicon sequencing data, shotgun metagenomics data, and metabolomics data. Min. reqs. include: Ph.D. in bioinformatics, ecology, microbiology or similar field. Proficient in coding languages (Python preferred). Demonstrated knowledge of …

An informative glimpse into the drug factory microbiome: Which bugs coexist with our drugs? The story behind the paper

The story behind: Toward the Drug Factory Microbiome: Microbial Community Variations in Antibiotic-Producing Clean Rooms (OMICS. 2018 Feb;22(2):133-144. doi: 10.1089/omi.2017.0091.) PMID: 28873001 [Preprint] It was in 2013, on my return to Cairo University after a couple of years as a visiting scientist at UCSD, that I met Amal for the first time. Amal was a fresh master’s …

New Report: Environmental Chemicals, the Human Microbiome, and Health Risk: a Research Strategy

​This seems likely to be of interest to many​ – got this via email. New Report: Environmental Chemicals, the Human Microbiome, and Health Risk: a Research Strategy The human microbiome is composed of a great number of diverse microorganisms that inhabit the human body. Until recently, the role of the microbiome in maintaining human health …