Paper of interest: Predicting antibiotic resistance from full genome sequences 

This preprint seems like it may be of interest to folks: Precise prediction of antibiotic resistance in Escherichia coli from full genome sequences | bioRxiv Basically, the authors showed that, using a machine learning approach, they can quite accurately predict antibiotic resistance in E. coli from whole genome data. The emergence of microbial antibiotic resistance …

A microbial sequencing discussion course built around a paper and a blog post

So – just a quick post for now.  More details to come.  But I wanted to get a little bit about this out there. For a few years I have been teaching a mid-level course at UC Davis on “DNA sequencing based studies of microbial diversity’.  The course has evolved over the years from a …

Postdoc Opportunity for Computational Microbial Ecologist in Seattle

  The Gibbons group at the Institute for Systems Biology (ISB) is seeking a computationally-oriented Postdoctoral Fellow with interests in microbial ecology, evolution, and human health. The successful applicant will work with an interdisciplinary team of microbiologists, systems biologists, bioinformaticians, and clinical researchers to:  Integrate and analyze multi-omic data from Arivale as part of the …

Help wanted: looking for a recent (post 2012) #openaccess review on molecular phylogenetic methods

I am getting ready for my “EVE161” class on Sequence based studies of the diversity of microbes.  For more about past versions of the class see here: https://www.microbe.net/eve161/. Anyway – I am working on the reading for the class and I am looking for a good, recent, open access review of molecular phylogenetic methods.  Any recommendations …

Why genome completeness and contamination estimates are more complicated than you think

Genome-resolved metagenomics is the process of recovering de novo genomes belonging to individual organisms present in a community using DNA extracted from the whole community. These genomes are sometimes referred to as MAGs (metagenome-assembled genomes), and are recovered by associating assembled contigs together in “bins” in a process known as genome binning. As opposed to …

Paper generating a lot of buzz: Nucleic acid purification from plants, animals and microbes in under 30 seconds

Well, this paper is generating a lot of buzz on social media.  Nucleic acid purification from plants, animals and microbes in under 30 seconds.  For example see Eric Topol’s Tweet about it Now this is innovative: paper dipstick extraction of DNA or RNA in < 30 seconds https://t.co/RKuLsAW7fM @PLOSBiology @UQ_News pic.twitter.com/FH1krTFYMw — Eric Topol (@EricTopol) …